Quick, name a fantasy RPG, one of the old pen-and-paper types. What did you say? Dungeons and Dragons, probably. Maybe not though, maybe it was Pathfinder, or Exalted, or Dark Sun, or Nobilis if you're so indie it hurts. Now name one with an SF setting. Shadowrun! Except that has magic too. Cyberpunk 2020, you offer, tentative because it's such an ungainly system. GURPS? Yes indeed, there is a great lack of role playing games set in the bold future instead of the never-past, and I've never understood the reason for this. Surely we ought to get more excitement out of imagining our possible futures than remixed editions of fairy tales, that owe their origins to a time when a pointy rock was seen as the pinnacle of human science and engineering.
Seems like someone out there agrees with me. Specifically, those ones are Posthuman Studios. And that agreement is Eclipse Phase.